STRESS & ENDOTHELIAL PHYSIOLOGY
AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Science Signaling. 2017 Jan 31;10(464) PubMed
Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY.
Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome..
BMC Systems Biology. 2015 Mar 11; 9: 13 PubMed
Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy JY.
MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2014 Jul; 34 (7) PubMed
Wang KC, Nguyen P, Weiss A, Yeh YT, Chien HS, Lee A, Teng D, Subramaniam S, Li YS, Chien S.
Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state.
Free Radical Biology & Medicine. 2013 Sep; 64: 61-8 PubMed
Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy JY.
Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.
Genes & Development. 2012 Dec 1; 26 (23): 2567–2579 PubMed
Colas AR, McKeithan WL, Cunningham TJ, Bushway PJ, Garmire LX, Duester G, Subramaniam S, Mercola M.
PEG-albumin plasma expansion increases expression of MCP-1 evidencing increased circulatory wall shear stress: an experimental study.
PLoS One. 2012 Jun 14; 7 (6): e39111 PubMed
Hightower CM, Salazar Vázquez BY, Acharya SA, Subramaniam S, Intaglietta M.
MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation.
Proc Natl Academy Sci USA. 2011 Jun 21; 108(25): 10355–10360 PubMed
Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S.
Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth.
Proceedings of the National Academy of Sciences of the USA. 2010 Feb 16; 107 (7): 3234-3239 PubMed
Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S.