Alliance for Cellular Signaling

The first of 5 National Institute of General Medical Sciences (NIGMS) Glue Grants, the AfCS-Nature Signaling Gateway is a comprehensive and up-to-the-minute resource for anyone interested in signal transduction. This Gateway represents a unique collaboration between academia and scientific publishing and is designed to facilitate navigation of the complex world of research into cellular signaling. Information and data presented here are freely available to all.

Biology Workbench

The Biology Workbench is a web-based tool for biologists. The WorkBench allows biologists to search many popular protein and nucleic acid sequence databases. Database searching is integrated with access to a wide variety of analysis and modeling tools, all within a point and click interface that eliminates file format compatibility problems.

Lipid Maps

The fifth of 5 National Institute of General Medical Sciences (NIGMS) Glue GrantsLIPID MAPS is an acronym for "Lipid Metabolites and Pathways Strategy". This consortium aims to focus on the lipid section of the metabolome by developing an integrated metabolomic system capable of characterizing the global changes in lipid metabolites ("lipidomics"). Specific consortium goals are to:

  • Separate and detect all of the lipids in a specific cell and discover and characterize any novel lipids that may be present.
  • Quantitate each of the lipid metabolites present and quantitate the changes in their levels and location during cellular function.
  • Define the biochemical pathways for each lipid and develop lipid maps which define the interaction networks.


MitoProteome is an object-relational mitochondrial protein sequence database generated from experimental evidence and public databases, and containing both mitochondrial- and nuclear-encoded entries. Each protein is extensively annotated with data extracted from external databases, including: Gene data extracted from LocusLink and Ensembl; Disease data extracted from OMIM; Interaction data extracted from MINT and DIP; Protein family data extracted from PFAM; Domain and Motif data extracted from InterPro; Fingerprint data extracted from PRINTS; and BLAST hits extracted from NCBI NR